1EPQ

ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-133,450 (SOT PHE GLY+SCC GCL)

1EPQ の概要

• エントリーDOI: 10.2210/pdb1epq/pdb
• 関連するPDBエントリー: 1epp
• 関連するBIRD辞書のPRD_ID: PRD_000356
• 分子名称: ENDOTHIAPEPSIN, N-[(1S)-2-{[(2S,3R,4S)-1-cyclohexyl-3,4-dihydroxy-6-methylheptan-2-yl]amino}-1-(ethylsulfanyl)-2-oxoethyl]-Nalpha-(morpholin-4-ylsulfonyl)-L-phenylalaninamide, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, acid proteinase, hydrolase/hydrolase inhibitor
• 由来する生物種: Cryphonectria parasitica (chestnut blight fungus)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34662.88

構造登録者

Dealwis, C.,Cooper, J.B.,Blundell, T.L. (登録日: 1994-07-27, 公開日: 1994-12-20, 最終更新日: 2020-05-27)

• 主引用文献: Lunney, E.A.,Hamilton, H.W.,Hodges, J.C.,Kaltenbronn, J.S.,Repine, J.T.,Badasso, M.,Cooper, J.B.,Dealwis, C.,Wallace, B.A.,Lowther, W.T.; Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.; J.Med.Chem., 36:3809-3820, 1993; PubMed: 8254610; DOI: 10.1021/jm00076a008

実験手法