1EPP

ENDOTHIA ASPARTIC PROTEINASE (ENDOTHIAPEPSIN) COMPLEXED WITH PD-130,693 (MAS PHE LYS+MTF STA MBA)

1EPP の概要

• エントリーDOI: 10.2210/pdb1epp/pdb
• 関連するPDBエントリー: 1EPQ
• 関連するBIRD辞書のPRD_ID: PRD_000392
• 分子名称: ENDOTHIAPEPSIN, SULFATE ION, N-(dimethylsulfamoyl)-L-phenylalanyl-N-[(1S,2S)-2-hydroxy-4-{[(2S)-2-methylbutyl]amino}-1-(2-methylpropyl)-4-oxobutyl]-N~6~-(methylcarbamothioyl)-L-lysinamide, ... (4 entities in total)
• 機能のキーワード: hydrolase-hydrolase inhibitor complex, acid proteinase, hydrolase/hydrolase inhibitor
• 由来する生物種: Cryphonectria parasitica (chestnut blight fungus)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 34705.95

構造登録者

Wallace, B.A.,Cooper, J.B.,Blundell, T.L. (登録日: 1994-07-27, 公開日: 1994-12-20, 最終更新日: 2017-11-29)

• 主引用文献: Lunney, E.A.,Hamilton, H.W.,Hodges, J.C.,Kaltenbronn, J.S.,Repine, J.T.,Badasso, M.,Cooper, J.B.,Dealwis, C.,Wallace, B.A.,Lowther, W.T.; Analyses of ligand binding in five endothiapepsin crystal complexes and their use in the design and evaluation of novel renin inhibitors.; J.Med.Chem., 36:3809-3820, 1993; PubMed: 8254610; DOI: 10.1021/jm00076a008

実験手法

X-RAY DIFFRACTION (1.9 Å)