1EFH

CRYSTAL STRUCTURE OF THE HUMAN HYDROXYSTEROID SULFOTRANSFERASE IN THE PRESENCE OF PAP

1EFH の概要

• エントリーDOI: 10.2210/pdb1efh/pdb
• 分子名称: HYDROXYSTEROID SULFOTRANSFERASE, ADENOSINE-3'-5'-DIPHOSPHATE (3 entities in total)
• 機能のキーワード: hydroxysteroid, sulfotransferase, dhea, a3p, paps, sult2a3, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 69945.63

構造登録者

Pedersen, L.C.,Petrotchenko, E.V.,Negishi, M. (登録日: 2000-02-08, 公開日: 2000-09-06, 最終更新日: 2024-02-07)

主引用文献

Pedersen, L.C.,Petrotchenko, E.V.,Negishi, M.
Crystal structure of SULT2A3, human hydroxysteroid sulfotransferase.
FEBS Lett., 475:61-64, 2000

PubMed Abstract: The crystal structure of SULT2A3 human hydroxysteroid sulfotransferase has been solved at 2.4 A resolution in the presence of 3'-phosphoadenosine 5'-phosphate (PAP). The overall structure is similar to those of SULT1 enzymes such as estrogen sulfotransferase and the PAP binding site is conserved, however, significant differences exist in the positions of loops Pro14-Ser20, Glu79-Ile82 and Tyr234-Gln244 in the substrate binding pocket. Moreover, protein interaction in the crystal structure has revealed a possible dimer-directed conformational alteration that may regulate the SULT activity.

PubMed: 10854859
DOI: 10.1016/S0014-5793(00)01479-4

実験手法

X-RAY DIFFRACTION (2.4 Å)