1EF7

CRYSTAL STRUCTURE OF HUMAN CATHEPSIN X

1EF7 の概要

• エントリーDOI: 10.2210/pdb1ef7/pdb
• 分子名称: CATHEPSIN X (2 entities in total)
• 機能のキーワード: papain-like, cysteine protease, carboxypeptidase, cathepsin, hydrolase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Lysosome: Q9UBR2
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 54354.19

構造登録者

Guncar, G.,Klemencic, I.,Turk, B.,Turk, V.,Karaoglanovic-Carmona, A.,Juliano, L.,Turk, D. (登録日: 2000-02-07, 公開日: 2000-03-15, 最終更新日: 2024-10-30)

主引用文献

Guncar, G.,Klemencic, I.,Turk, B.,Turk, V.,Karaoglanovic-Carmona, A.,Juliano, L.,Turk, D.
Crystal structure of cathepsin X: a flip-flop of the ring of His23 allows carboxy-monopeptidase and carboxy-dipeptidase activity of the protease.
Structure Fold.Des., 8:305-313, 2000

PubMed Abstract: Cathepsin X is a widespread, abundantly expressed papain-like mammalian lysosomal cysteine protease. It exhibits carboxy-monopeptidase as well as carboxy-dipeptidase activity and shares a similar activity profile with cathepsin B. The latter has been implicated in normal physiological events as well as in various pathological states such as rheumatoid arthritis, Alzheimer's disease and cancer progression. Thus the question is raised as to which of the two enzyme activities has actually been monitored.

PubMed: 10745011
DOI: 10.1016/S0969-2126(00)00108-8

実験手法

X-RAY DIFFRACTION (2.67 Å)