1EF3
FIDARESTAT BOUND TO HUMAN ALDOSE REDUCTASE
Summary for 1EF3
Entry DOI | 10.2210/pdb1ef3/pdb |
Descriptor | ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, ... (4 entities in total) |
Functional Keywords | beta barrel, protein-inhibitor complex, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 2 |
Total formula weight | 73579.55 |
Authors | Oka, M.,Matsumoto, Y.,Sugiyama, S.,Tsuruta, N.,Matsushima, M. (deposition date: 2000-02-06, release date: 2001-02-07, Last modification date: 2023-08-09) |
Primary citation | Oka, M.,Matsumoto, Y.,Sugiyama, S.,Tsuruta, N.,Matsushima, M. A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography. J.Med.Chem., 43:2479-2483, 2000 Cited by PubMed: 10882376DOI: 10.1021/jm990502r PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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