1EET
HIV-1 REVERSE TRANSCRIPTASE IN COMPLEX WITH THE INHIBITOR MSC204
Summary for 1EET
Entry DOI | 10.2210/pdb1eet/pdb |
Related | 1HAR |
Descriptor | HIV-1 REVERSE TRANSCRIPTASE, 1-(5-BROMO-PYRIDIN-2-YL)-3-[2-(6-FLUORO-2-HYDROXY-3-PROPIONYL-PHENYL)-CYCLOPROPYL]-UREA, ... (4 entities in total) |
Functional Keywords | heterodimer, protein-inhibitor complex, viral protein, transferase |
Biological source | Human immunodeficiency virus 1 More |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03366 P03366 |
Total number of polymer chains | 2 |
Total formula weight | 114510.22 |
Authors | Hogberg, M.,Sahlberg, C.,Engelhardt, P.,Noreen, R.,Kangasmetsa, J.,Johansson, N.G.,Oberg, B.,Vrang, L.,Zhang, H.,Sahlberg, B.L.,Unge, T.,Lovgren, S.,Fridborg, K.,Backbro, K. (deposition date: 2000-02-03, release date: 2001-02-07, Last modification date: 2024-02-07) |
Primary citation | Hogberg, M.,Sahlberg, C.,Engelhardt, P.,Noreen, R.,Kangasmetsa, J.,Johansson, N.G.,Oberg, B.,Vrang, L.,Zhang, H.,Sahlberg, B.L.,Unge, T.,Lovgren, S.,Fridborg, K.,Backbro, K. Urea-PETT compounds as a new class of HIV-1 reverse transcriptase inhibitors. 3. Synthesis and further structure-activity relationship studies of PETT analogues. J.Med.Chem., 42:4150-4160, 1999 Cited by PubMed: 10514285DOI: 10.1021/jm990572y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.73 Å) |
Structure validation
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