1EEM

GLUTATHIONE TRANSFERASE FROM HOMO SAPIENS

1EEM の概要

• エントリーDOI: 10.2210/pdb1eem/pdb
• 分子名称: GLUTATHIONE-S-TRANSFERASE, SULFATE ION, GLUTATHIONE, ... (4 entities in total)
• 機能のキーワード: gst, glutathione conjugating, putative oxidoreductase, transferase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm, cytosol : P78417
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 28099.30

構造登録者

Board, P.,Coggan, M.,Chelvanayagam, G.,Easteal, S.,Jermiin, L.S.,Schulte, G.K.,Danley, D.E.,Hoth, L.R.,Griffor, M.C.,Kamath, A.V.,Rosner, M.H.,Chrunyk, B.A.,Perregaux, D.E.,Gabel, C.A.,Geoghegan, K.F.,Pandit, J. (登録日: 2000-02-01, 公開日: 2000-08-11, 最終更新日: 2018-04-04)

主引用文献

Board, P.G.,Coggan, M.,Chelvanayagam, G.,Easteal, S.,Jermiin, L.S.,Schulte, G.K.,Danley, D.E.,Hoth, L.R.,Griffor, M.C.,Kamath, A.V.,Rosner, M.H.,Chrunyk, B.A.,Perregaux, D.E.,Gabel, C.A.,Geoghegan, K.F.,Pandit, J.
Identification, characterization, and crystal structure of the Omega class glutathione transferases.
J.Biol.Chem., 275:24798-24806, 2000

PubMed Abstract: A new class of glutathione transferases has been discovered by analysis of the expressed sequence tag data base and sequence alignment. Glutathione S-transferases (GSTs) of the new class, named Omega, exist in several mammalian species and Caenorhabditis elegans. In humans, GSTO 1-1 is expressed in most tissues and exhibits glutathione-dependent thiol transferase and dehydroascorbate reductase activities characteristic of the glutaredoxins. The structure of GSTO 1-1 has been determined at 2.0-A resolution and has a characteristic GST fold (Protein Data Bank entry code ). The Omega class GSTs exhibit an unusual N-terminal extension that abuts the C terminus to form a novel structural unit. Unlike other mammalian GSTs, GSTO 1-1 appears to have an active site cysteine that can form a disulfide bond with glutathione.

PubMed: 10783391
DOI: 10.1074/jbc.M001706200

実験手法

X-RAY DIFFRACTION (2 Å)