1EDN

HUMAN ENDOTHELIN-1

Summary for 1EDN

• Entry DOI: 10.2210/pdb1edn/pdb
• Descriptor: ENDOTHELIN-1 (1 entity in total)
• Functional Keywords: signal polypeptide g-protein coupled-receptor ligand, vasoconstrictor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 2497.95

Authors

Wallace, B.A.,Janes, R.W. (deposition date: 1994-09-19, release date: 1995-10-15, Last modification date: 2024-10-23)

Primary citation

Janes, R.W.,Peapus, D.H.,Wallace, B.A.
The crystal structure of human endothelin.
Nat.Struct.Biol., 1:311-319, 1994

PubMed Abstract: The three-dimensional structure of the vasoactive polypeptide endothelin, the most potent vasoconstrictor yet identified, has been determined by X-ray crystallography to 2.18 A resolution. This intermediate-sized structure was solved by molecular replacement techniques using a fragment of an NMR-derived model for initial phasing of the data. However, comparisons of the final X-ray structure with the many diverse models derived from NMR data indicate some important differences, especially in the carboxy-terminal region of the molecule: the entire carboxy terminal tail (residues 16-21) is helical in the crystal structure, but not in any of the NMR structures. This may be a functionally significant difference as this region is crucial for receptor binding and vasoactivity.

PubMed: 7664037
DOI: 10.1038/nsb0594-311

Experimental method

X-RAY DIFFRACTION (2.18 Å)