1EC4

SOLUTION STRUCTURE OF A HEXITOL NUCLEIC ACID DUPLEX WITH FOUR CONSECUTIVE T:T BASE PAIRS

Summary for 1EC4

• Entry DOI: 10.2210/pdb1ec4/pdb
• Related: 205D 280D
• Descriptor: HEXITOL DODECANUCLEOTIDE (1 entity in total)
• Functional Keywords: double helix, antisense, hexitol nucleic acid, dna
• Total number of polymer chains: 2
• Total formula weight: 7627.38

Authors

Lescrinier, E.,Esnouf, R.M.,Schraml, J.,Busson, R.,Herdewijn, P. (deposition date: 2000-01-25, release date: 2003-04-22, Last modification date: 2024-05-22)

Primary citation

Lescrinier, E.,Esnouf, R.M.,Schraml, J.,Busson, R.,Heus, H.A.,Hilbers, C.W.,Herdewijn, P.
Solution structure of a HNA-RNA hybrid
Chem.Biol., 7:719-731, 2000

PubMed Abstract: Synthetic nucleic acid analogues with a conformationally restricted sugar-phosphate backbone are widely used in antisense strategies for biomedical and biochemical applications. The modified backbone protects the oligonucleotides against degradation within the living cell, which allows them to form stable duplexes with sequences in target mRNAs with the aim of arresting their translation. The biologically most active antisense oligonucleotides also trigger cleavage of the target RNA through activation of endogenous RNase H. Systematic studies of synthetic oligonucleotides have also been conducted to delineate the origin of the chirality of DNA and RNA that are both composed of D-nucleosides.

PubMed: 10980452
DOI: 10.1016/S1074-5521(00)00017-X

Experimental method

SOLUTION NMR