1EBP
COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN AGONIST PEPTIDE [EMP1]
Summary for 1EBP
Entry DOI | 10.2210/pdb1ebp/pdb |
Descriptor | EPO RECEPTOR, EPO MIMETICS PEPTIDE 1 (2 entities in total) |
Functional Keywords | erythropoietin receptor, signal transduction, protein minimization, drug design, cytokine receptor class 1, complex (cytokine receptor-peptide), complex (cytokine receptor-peptide) complex, complex (cytokine receptor/peptide) |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane; Single-pass type I membrane protein. Isoform EPOR-S: Secreted: P19235 |
Total number of polymer chains | 4 |
Total formula weight | 50849.69 |
Authors | Livnah, O.,Stura, E.A.,Wilson, I.A. (deposition date: 1996-05-07, release date: 1997-07-29, Last modification date: 2024-06-05) |
Primary citation | Livnah, O.,Stura, E.A.,Johnson, D.L.,Middleton, S.A.,Mulcahy, L.S.,Wrighton, N.C.,Dower, W.J.,Jolliffe, L.K.,Wilson, I.A. Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A. Science, 273:464-471, 1996 Cited by PubMed: 8662530PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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