1EBD

DIHYDROLIPOAMIDE DEHYDROGENASE COMPLEXED WITH THE BINDING DOMAIN OF THE DIHYDROLIPOAMIDE ACETYLASE

1EBD の概要

• エントリーDOI: 10.2210/pdb1ebd/pdb
• 分子名称: DIHYDROLIPOAMIDE DEHYDROGENASE, DIHYDROLIPOAMIDE ACETYLTRANSFERASE, FLAVIN-ADENINE DINUCLEOTIDE, ... (4 entities in total)
• 機能のキーワード: redox-active center, glycolysis, oxidoreductase, complex (oxidoreductase-transferase) complex, complex (oxidoreductase/transferase)
• 由来する生物種: Geobacillus stearothermophilus; 詳細
• 細胞内の位置: Cytoplasm: P11959
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 101600.13

構造登録者

Mande, S.S.,Sarfaty, S.,Allen, M.D.,Perham, R.N.,Hol, W.G.J. (登録日: 1996-02-03, 公開日: 1996-07-11, 最終更新日: 2024-10-23)

主引用文献

Mande, S.S.,Sarfaty, S.,Allen, M.D.,Perham, R.N.,Hol, W.G.
Protein-protein interactions in the pyruvate dehydrogenase multienzyme complex: dihydrolipoamide dehydrogenase complexed with the binding domain of dihydrolipoamide acetyltransferase.
Structure, 4:277-286, 1996

PubMed Abstract: The ubiquitous pyruvate dehydrogenase multienzyme complex is built around an octahedral or icosahedral core of dihydrolipoamide acetyltransferase (E2) chains, to which multiple copies of pyruvate decarboxylase (E1) and dihydrolipoamide dehydrogenase (E3) bind tightly but non-covalently. E2 is a flexible multidomain protein that mediates interactions with E1 and E3 through a remarkably small binding domain (E2BD).

PubMed: 8805537
DOI: 10.1016/S0969-2126(96)00032-9

実験手法

X-RAY DIFFRACTION (2.6 Å)