1EBA

COMPLEX BETWEEN THE EXTRACELLULAR DOMAIN OF ERYTHROPOIETIN (EPO) RECEPTOR [EBP] AND AN INACTIVE PEPTIDE [EMP33] CONTAINS 3,5-DIBROMOTYROSINE IN POSITION 4 (DENOTED DBY)

1EBA の概要

• エントリーDOI: 10.2210/pdb1eba/pdb
• 分子名称: PROTEIN (ERYTHROPOIETIN RECEPTOR), PROTEIN (EPO MIMETICS PEPTIDE 33) (2 entities in total)
• 機能のキーワード: erythropoietin receptor, signal transduction, protein minimization, drug design, cytokine receptor class 1, complex (cytokine receptor-peptide), signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cell membrane; Single-pass type I membrane protein. Isoform EPOR-S: Secreted: P19235
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 51990.15

構造登録者

Livnah, O.,Stura, E.A.,Wilson, I.A. (登録日: 1998-10-02, 公開日: 1998-11-11, 最終更新日: 2023-08-09)

• 主引用文献: Livnah, O.,Johnson, D.L.,Stura, E.A.,Farrell, F.X.,Barbone, F.P.,You, Y.,Liu, K.D.,Goldsmith, M.A.,He, W.,Krause, C.D.,Pestka, S.,Jolliffe, L.K.,Wilson, I.A.; An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation.; Nat.Struct.Biol., 5:993-1004, 1998; PubMed: 9808045; DOI: 10.1038/2965

実験手法

X-RAY DIFFRACTION (2.7 Å)