1EAI

COMPLEX OF ASCARIS CHYMOTRPSIN/ELASTASE INHIBITOR WITH PORCINE ELASTASE

Summary for 1EAI

• Entry DOI: 10.2210/pdb1eai/pdb
• Descriptor: PROTEIN (ELASTASE), PROTEIN (CHYMOTRYPSIN/ELASTASE ISOINHIBITOR 1) (3 entities in total)
• Functional Keywords: serine proteinase, elastase, ascaris summ, protein inhibitor
• Biological source: Sus scrofa (pig); More
• Cellular location: Secreted: P00772 P07851
• Total number of polymer chains: 4
• Total formula weight: 65063.08

Authors

Huang, K.,Strynadka, N.C.J.,Bernard, V.D.,Peanasky, R.J.,James, M.N.G. (deposition date: 1999-03-25, release date: 1999-04-05, Last modification date: 2024-10-09)

Primary citation

Huang, K.,Strynadka, N.C.,Bernard, V.D.,Peanasky, R.J.,James, M.N.
The molecular structure of the complex of Ascaris chymotrypsin/elastase inhibitor with porcine elastase.
Structure, 2:679-689, 1994

PubMed Abstract: The intestinal parasitic worm, Ascaris suum, produces a variety of protein inhibitors that defend the organism against the host's proteinases. Eight different proteins from Ascaris suum have been identified as inhibitors of serine proteinases, targeting chymotrypsin, elastase and trypsin. These inhibitors share 30-40% sequence identity with one another, but have virtually no sequence identity with members of any of the other families of serine proteinase inhibitors.

PubMed: 7922044
DOI: 10.1016/S0969-2126(00)00068-X

Experimental method

X-RAY DIFFRACTION (2.4 Å)