1EAH

PV2L COMPLEXED WITH ANTIVIRAL AGENT SCH48973

Summary for 1EAH

• Entry DOI: 10.2210/pdb1eah/pdb
• Descriptor: POLIOVIRUS TYPE 2 COAT PROTEINS VP1 TO VP4, 1[2-CHLORO-4-METHOXY-PHENYL-OXYMETHYL]-4-[2,6-DICHLORO-PHENYL-OXYMETHYL]-BENZENE, MYRISTIC ACID, ... (7 entities in total)
• Functional Keywords: type 2, lansing, antiviral, picornavirus, mouse neurovirulence, coat protein, icosahedral virus, virus
• Biological source: Human poliovirus 2; More
• Cellular location: Protein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential): P06210 P06210 P06210 P06210
• Total number of polymer chains: 4
• Total formula weight: 97491.30

Authors

Lentz, K.,Arnold, E. (deposition date: 1997-07-22, release date: 1998-09-16, Last modification date: 2024-11-20)

Primary citation

Lentz, K.N.,Smith, A.D.,Geisler, S.C.,Cox, S.,Buontempo, P.,Skelton, A.,DeMartino, J.,Rozhon, E.,Schwartz, J.,Girijavallabhan, V.,O'Connell, J.,Arnold, E.
Structure of poliovirus type 2 Lansing complexed with antiviral agent SCH48973: comparison of the structural and biological properties of three poliovirus serotypes.
Structure, 5:961-978, 1997

PubMed Abstract: Polioviruses are human pathogens and the causative agents of poliomyelitis. Polioviruses are icosahedral single-stranded RNA viruses, which belong to the picornavirus family, and occur as three distinct serotypes. All three serotypes of poliovirus can infect primates, but only type 2 can infect mice. The crystal structures of a type 1 and a type 3 poliovirus are already known. Structural studies of poliovirus type 2 Lansing (PV2L) were initiated to try to enhance our understanding of the differences in host range specificity, antigenicity and receptor binding among the three serotypes of poliovirus.

PubMed: 9261087
DOI: 10.1016/S0969-2126(97)00249-9

Experimental method

X-RAY DIFFRACTION (2.9 Å)