1E3H

SeMet derivative of Streptomyces antibioticus PNPase/GPSI enzyme

1E3H の概要

• エントリーDOI: 10.2210/pdb1e3h/pdb
• 関連するPDBエントリー: 1E3P
• 分子名称: GUANOSINE PENTAPHOSPHATE SYNTHETASE, SULFATE ION (3 entities in total)
• 機能のキーワード: polyribonucleotide transferase, atp:gtp diphosphotransferase, rna processing, rna degradation
• 由来する生物種: STREPTOMYCES ANTIBIOTICUS
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 83027.86

構造登録者

Symmons, M.F.,Jones, G.H.,Luisi, B.F. (登録日: 2000-06-15, 公開日: 2000-11-05, 最終更新日: 2024-10-23)

主引用文献

Symmons, M.F.,Jones, G.H.,Luisi, B.F.
A Duplicated Fold is the Structural Basis for Polynucleotide Phosphorylase Catalytic Activity, Processivity, and Regulation
Structure, 8:1215-, 2000

PubMed Abstract: Polynucleotide phosphorylase (PNPase) is a polyribonucleotide nucleotidyl transferase (E.C.2.7.7.8) that degrades mRNA in prokaryotes. Streptomyces antibioticus PNPase also assays as a guanosine 3'-diphosphate 5'-triphosphate (pppGpp) synthetase (E.C.2.7.6.5). It may function to coordinate changes in mRNA lifetimes with pppGpp levels during the Streptomyces lifecycle.

PubMed: 11080643
DOI: 10.1016/S0969-2126(00)00521-9

実験手法

X-RAY DIFFRACTION (2.6 Å)