1E31

SURVIVIN DIMER H. SAPIENS

1E31 の概要

• エントリーDOI: 10.2210/pdb1e31/pdb
• 分子名称: APOPTOSIS INHIBITOR SURVIVIN, ZINC ION, COBALT (II) ION, ... (4 entities in total)
• 機能のキーワード: apoptosis inhibitor, iap, apotosis, zinc finger
• 由来する生物種: HOMO SAPIENS (HUMAN)
• 細胞内の位置: Cytoplasm: O15392
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 33019.22

構造登録者

Chantalat, L.,Skoufias, D.A.,Margolis, R.L.,Dideberg, O. (登録日: 2000-06-04, 公開日: 2001-01-03, 最終更新日: 2024-05-08)

主引用文献

Chantalat, L.,Skoufias, D.A.,Kleman, J.P.,Jung, B.,Dideberg, O.,Margolis, R.L.
Crystal Structure of Human Survivin Reveals a Bow Tie-Shaped Dimer with Two Unusual Alpha-Helical Extensions
Mol.Cell, 6:183-, 2000

PubMed Abstract: Survivin is a mitotic spindle-associated protein involved in linking mitotic spindle function to activation of apoptosis in mammalian cells. The structure of the full-length human survivin has been determined by X-ray crystallography to 2.7 A. Strikingly, the structure forms a very unusual bow tie-shaped dimer. It does not dimerize through a C-terminal coiled-coil, contrary to sequence analysis prediction. The C-terminal helices contain hydrophobic clusters with the potential for protein-protein interactions. The unusual shape and dimensions of survivin suggest it serves an adaptor function through its alpha-helical extensions.

PubMed: 10949039
DOI: 10.1016/S1097-2765(00)00019-8

実験手法

X-RAY DIFFRACTION (2.71 Å)