1E0B

Chromo shadow domain from fission yeast swi6 protein.

Summary for 1E0B

Entry DOI	10.2210/pdb1e0b/pdb
Descriptor	SWI6 PROTEIN, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL (3 entities in total)
Functional Keywords	chromatin-binding, chromodomain, shadow, heterochromatin, swi6, pombe
Biological source	SCHIZOSACCHAROMYCES POMBE
Total number of polymer chains	2
Total formula weight	16394.15
Authors	Cowieson, N.P.,Partridge, J.F.,Allshire, R.C.,Mclaughlin, P.J. (deposition date: 2000-03-16, release date: 2000-05-12, Last modification date: 2024-05-08)
Primary citation	Cowieson, N.P.,Partridge, J.F.,Allshire, R.C.,Mclaughlin, P.J. Dimerisation of Chromo Shadow Domain and Distinctions from the Chromodomain as Revealed by Structural Analysis Curr.Biol., 10:517-, 2000 Cited by PubMed Abstract: Proteins such as HP1, found in fruit flies and mammals, and Swi6, its fission yeast homologue, carry a chromodomain (CD) and a chromo shadow domain (CSD). These proteins are required to form functional transcriptionally silent centromeric chromatin, and their mutation leads to chromosome segregation defects. CSDs have only been found in tandem in proteins containing the related CD. Most HP1-interacting proteins have been found to associate through the CSD and many of these ligands contain a conserved pentapeptide motif. PubMed: 10801440 DOI: 10.1016/S0960-9822(00)00467-X PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation