1E0B

Chromo shadow domain from fission yeast swi6 protein.

1E0B の概要

• エントリーDOI: 10.2210/pdb1e0b/pdb
• 分子名称: SWI6 PROTEIN, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL (3 entities in total)
• 機能のキーワード: chromatin-binding, chromodomain, shadow, heterochromatin, swi6, pombe
• 由来する生物種: SCHIZOSACCHAROMYCES POMBE
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 16394.15

構造登録者

Cowieson, N.P.,Partridge, J.F.,Allshire, R.C.,Mclaughlin, P.J. (登録日: 2000-03-16, 公開日: 2000-05-12, 最終更新日: 2024-05-08)

主引用文献

Cowieson, N.P.,Partridge, J.F.,Allshire, R.C.,Mclaughlin, P.J.
Dimerisation of Chromo Shadow Domain and Distinctions from the Chromodomain as Revealed by Structural Analysis
Curr.Biol., 10:517-, 2000

PubMed Abstract: Proteins such as HP1, found in fruit flies and mammals, and Swi6, its fission yeast homologue, carry a chromodomain (CD) and a chromo shadow domain (CSD). These proteins are required to form functional transcriptionally silent centromeric chromatin, and their mutation leads to chromosome segregation defects. CSDs have only been found in tandem in proteins containing the related CD. Most HP1-interacting proteins have been found to associate through the CSD and many of these ligands contain a conserved pentapeptide motif.

PubMed: 10801440
DOI: 10.1016/S0960-9822(00)00467-X

実験手法

X-RAY DIFFRACTION (1.9 Å)