1DYR

THE STRUCTURE OF PNEUMOCYSTIS CARINII DIHYDROFOLATE REDUCTASE TO 1.9 ANGSTROMS RESOLUTION

1DYR の概要

• エントリーDOI: 10.2210/pdb1dyr/pdb
• 分子名称: DIHYDROFOLATE REDUCTASE, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, TRIMETHOPRIM, ... (4 entities in total)
• 機能のキーワード: oxido-reductase, oxidoreductase
• 由来する生物種: Pneumocystis carinii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 24954.28

構造登録者

Champness, J.N.,Achari, A.,Ballantine, S.P.,Bryant, P.K.,Delves, C.J.,Stammers, D.K. (登録日: 1994-09-14, 公開日: 1995-10-15, 最終更新日: 2024-02-07)

主引用文献

Champness, J.N.,Achari, A.,Ballantine, S.P.,Bryant, P.K.,Delves, C.J.,Stammers, D.K.
The structure of Pneumocystis carinii dihydrofolate reductase to 1.9 A resolution.
Structure, 2:915-924, 1994

PubMed Abstract: The fungal pathogen Pneumocystis carinii causes a pneumonia which is an opportunistic infection of AIDS patients. Current therapy includes the dihydrofolate reductase (DHFR) inhibitor trimethoprim which is selective but only a relatively weak inhibitor of the enzyme for P. carinii. Determination of the three-dimensional structure of the enzyme should form the basis for design of more potent and selective therapeutic agents for treatment of the disease.

PubMed: 7866743
DOI: 10.1016/S0969-2126(94)00093-X

実験手法

X-RAY DIFFRACTION (1.86 Å)