1DUS

MJ0882-A hypothetical protein from M. jannaschii

1DUS の概要

• エントリーDOI: 10.2210/pdb1dus/pdb
• 分子名称: MJ0882 (2 entities in total)
• 機能のキーワード: hypothetical protein, methanococcus jannaschii, structural genomics, bsgc structure funded by nih, protein structure initiative, psi, berkeley structural genomics center
• 由来する生物種: Methanocaldococcus jannaschii
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 21945.17

構造登録者

Hung, L.,Huang, L.,Kim, R.,Kim, S.H.,Berkeley Structural Genomics Center (BSGC) (登録日: 2000-01-18, 公開日: 2000-07-19, 最終更新日: 2024-11-06)

主引用文献

Huang, L.,Hung, L.,Odell, M.,Yokota, H.,Kim, R.,Kim, S.H.
Structure-based experimental confirmation of biochemical function to a methyltransferase, MJ0882, from hyperthermophile Methanococcus jannaschii
J.STRUCT.FUNCT.GENOM., 2:121-127, 2002

PubMed Abstract: We have determined the three-dimensional (3-D) structure of protein MJ0882, which derives from a hypothetical open reading frame in the genome of the hyperthermophile Methanococcus jannaschii. The 3-D fold of MJ0882 at 1.8 A highly resembles that of a methyltransferase, despite limited sequence similarity to any confirmed methyltransferase. The structure has an S-adenosylmethionine (AdoMet) binding pocket surrounded by motifs with similarities to those commonly found among AdoMet binding proteins. Preliminary biochemical experiments show that MJ0882 specifically binds to AdoMet, which is the essential co-factor for methyltransferases.

PubMed: 12836702
DOI: 10.1023/A:1021279113558

実験手法

X-RAY DIFFRACTION (1.8 Å)