1DUH

CRYSTAL STRUCTURE OF THE CONSERVED DOMAIN IV OF E. COLI 4.5S RNA

1DUH の概要

• エントリーDOI: 10.2210/pdb1duh/pdb
• 分子名称: 4.5S RNA DOMAIN IV, LUTETIUM (III) ION, MAGNESIUM ION, ... (5 entities in total)
• 機能のキーワード: 4.5s rna, domain iv, helix 8, signal recognition particle, srp, ffh, srp54, elongation factor g, ef-g, 23s rna, non-canonical base pairs, mismatch, rna
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 15055.13

構造登録者

Jovine, L.,Hainzl, T.,Oubridge, C.,Scott, W.G.,Li, J.,Sixma, T.K.,Wonacott, A.,Skarzynski, T.,Nagai, K. (登録日: 2000-01-17, 公開日: 2000-05-08, 最終更新日: 2024-02-07)

主引用文献

Jovine, L.,Hainzl, T.,Oubridge, C.,Scott, W.G.,Li, J.,Sixma, T.K.,Wonacott, A.,Skarzynski, T.,Nagai, K.
Crystal structure of the ffh and EF-G binding sites in the conserved domain IV of Escherichia coli 4.5S RNA.
Structure Fold.Des., 8:527-540, 2000

PubMed Abstract: Bacterial signal recognition particle (SRP), consisting of 4.5S RNA and Ffh protein, plays an essential role in targeting signal-peptide-containing proteins to the secretory apparatus in the cell membrane. The 4.5S RNA increases the affinity of Ffh for signal peptides and is essential for the interaction between SRP and its receptor, protein FtsY. The 4.5S RNA also interacts with elongation factor G (EF-G) in the ribosome and this interaction is required for efficient translation.

PubMed: 10801497
DOI: 10.1016/S0969-2126(00)00137-4

実験手法

X-RAY DIFFRACTION (2.7 Å)