1DTS

CRYSTAL STRUCTURE OF AN ATP DEPENDENT CARBOXYLASE, DETHIOBIOTIN SYNTHASE, AT 1.65 ANGSTROMS RESOLUTION

1DTS の概要

• エントリーDOI: 10.2210/pdb1dts/pdb
• 分子名称: DETHIOBIOTIN SYNTHETASE (2 entities in total)
• 機能のキーワード: cyclo-ligase
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P13000
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 23705.05

構造登録者

Huang, W.,Lindqvist, Y.,Schneider, G. (登録日: 1995-03-28, 公開日: 1995-04-20, 最終更新日: 2024-02-07)

主引用文献

Huang, W.,Lindqvist, Y.,Schneider, G.,Gibson, K.J.,Flint, D.,Lorimer, G.
Crystal structure of an ATP-dependent carboxylase, dethiobiotin synthetase, at 1.65 A resolution.
Structure, 2:407-414, 1994

PubMed Abstract: In Escherichia coli, the enzymes of the biotin biosynthesis pathway are encoded by the bio operon. One of these enzymes, ATP-dependent dethiobiotin synthetase, catalyzes the carboxylation of 7,8-diaminopelargonic acid leading to the formation of the ureido ring of biotin. The enzyme belongs to the class of ATP-dependent carboxylases and we present here the first crystal structure determined for this class of enzyme.

PubMed: 8081756
DOI: 10.1016/S0969-2126(00)00042-3

実験手法

X-RAY DIFFRACTION (1.65 Å)