1DRH

ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS

Summary for 1DRH

Entry DOI	10.2210/pdb1drh/pdb
Descriptor	DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
Functional Keywords	oxidoreductase
Biological source	Escherichia coli
Total number of polymer chains	1
Total formula weight	18763.73
Authors	Sawaya, M.R.,Kraut, J. (deposition date: 1994-11-30, release date: 1995-02-07, Last modification date: 2024-02-07)
Primary citation	Reyes, V.M.,Sawaya, M.R.,Brown, K.A.,Kraut, J. Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications. Biochemistry, 34:2710-2723, 1995 Cited by PubMed: 7873554 DOI: 10.1021/bi00008a039 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation