1DRH

ISOMORPHOUS CRYSTAL STRUCTURES OF ESCHERICHIA COLI DIHYDROFOLATE REDUCTASE COMPLEXED WITH FOLATE, 5-DEAZAFOLATE AND 5,10-DIDEAZATETRAHYDROFOLATE: MECHANISTIC IMPLICATIONS

1DRH の概要

• エントリーDOI: 10.2210/pdb1drh/pdb
• 分子名称: DIHYDROFOLATE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE (3 entities in total)
• 機能のキーワード: oxidoreductase
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 18763.73

構造登録者

Sawaya, M.R.,Kraut, J. (登録日: 1994-11-30, 公開日: 1995-02-07, 最終更新日: 2024-02-07)

• 主引用文献: Reyes, V.M.,Sawaya, M.R.,Brown, K.A.,Kraut, J.; Isomorphous crystal structures of Escherichia coli dihydrofolate reductase complexed with folate, 5-deazafolate, and 5,10-dideazatetrahydrofolate: mechanistic implications.; Biochemistry, 34:2710-2723, 1995; PubMed: 7873554; DOI: 10.1021/bi00008a039

実験手法

X-RAY DIFFRACTION (2.3 Å)