1DPS

THE CRYSTAL STRUCTURE OF DPS, A FERRITIN HOMOLOG THAT BINDS AND PROTECTS DNA

1DPS の概要

• エントリーDOI: 10.2210/pdb1dps/pdb
• 分子名称: DPS, SODIUM ION (3 entities in total)
• 機能のキーワード: dna-binding protein, ferritin, iron sequestration, stationary phase, oxidative damage, dna binding protein
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm, nucleoid: P0ABT2
• タンパク質・核酸の鎖数: 12
• 化学式量合計: 225112.19

構造登録者

Grant, R.A.,Filman, D.J.,Finkel, S.E.,Kolter, R.,Hogle, J.M. (登録日: 1998-02-23, 公開日: 1998-09-16, 最終更新日: 2024-02-07)

主引用文献

Grant, R.A.,Filman, D.J.,Finkel, S.E.,Kolter, R.,Hogle, J.M.
The crystal structure of Dps, a ferritin homolog that binds and protects DNA.
Nat.Struct.Biol., 5:294-303, 1998

PubMed Abstract: The crystal structure of Dps, a DNA-binding protein from starved E. coli that protects DNA from oxidative damage, has been solved at 1.6 A resolution. The Dps monomer has essentially the same fold as ferritin, which forms a 24-mer with 432 symmetry, a hollow core and pores at the three-fold axes. Dps forms a dodecamer with 23 (tetrahedral) point group symmetry which also has a hollow core and pores at the three-folds. The structure suggests a novel DNA-binding motif and a mechanism for DNA protection based on the sequestration of Fe ions.

PubMed: 9546221
DOI: 10.1038/nsb0498-294

実験手法

X-RAY DIFFRACTION (1.6 Å)