1DNM

CRYSTAL STRUCTURE AND SEQUENCE-DEPENDENT CONFORMATION OF THE A.G MIS-PAIRED OLIGONUCLEOTIDE D(CGCAAGCTGGCG)

1DNM の概要

• エントリーDOI: 10.2210/pdb1dnm/pdb
• 分子名称: DNA (5'-D(*CP*GP*CP*AP*AP*GP*CP*TP*GP*GP*CP*G)-3') (2 entities in total)
• 機能のキーワード: b-dna, double helix, mismatched, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7376.81

構造登録者

Webster, G.D.,Sanderson, M.R.,Skelly, J.V.,Neidle, S.,Swann, P.F.,Li, B.F.,Tickle, I.J. (登録日: 1990-06-22, 公開日: 1991-07-15, 最終更新日: 2024-02-07)

主引用文献

Webster, G.D.,Sanderson, M.R.,Skelly, J.V.,Neidle, S.,Swann, P.F.,Li, B.F.,Tickle, I.J.
Crystal structure and sequence-dependent conformation of the A.G mispaired oligonucleotide d(CGCAAGCTGGCG).
Proc.Natl.Acad.Sci.USA, 87:6693-6697, 1990

PubMed Abstract: The crystal structure of the dodecanucleotide d(CGCAAGCTGGCG) has been determined to a resolution of 2.5 A and refined to an R factor of 19.3% for 1710 reflections. The sequence crystallizes as a B-type double helix, with two G(anti).A(syn) base pairs. These are stabilized by three-center hydrogen bonds to pyrimidines that induce perturbations in base-pair geometry. The central AGCT region of the helix has a wide (greater than 6 A) minor groove.

PubMed: 2395870
DOI: 10.1073/pnas.87.17.6693

実験手法

X-RAY DIFFRACTION (2.5 Å)