1DMO

CALMODULIN, NMR, 30 STRUCTURES

1DMO の概要

• エントリーDOI: 10.2210/pdb1dmo/pdb
• 分子名称: CALMODULIN (1 entity in total)
• 機能のキーワード: calcium-induced conformational change, calcium-binding protein
• 由来する生物種: Xenopus laevis (African clawed frog)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 16720.36

構造登録者

Zhang, M.,Tanaka, T.,Ikura, M. (登録日: 1996-04-24, 公開日: 1996-08-01, 最終更新日: 2024-05-22)

主引用文献

Zhang, M.,Tanaka, T.,Ikura, M.
Calcium-induced conformational transition revealed by the solution structure of apo calmodulin.
Nat.Struct.Biol., 2:758-767, 1995

PubMed Abstract: The solution structure of Ca(2+)-free calmodulin has been determined by NMR spectroscopy, and is compared to the previously reported structure of the Ca(2+)-saturated form. The removal of Ca2+ causes the interhelical angles of four EF-hand motifs to increase by 36 degrees-44 degrees. This leads to major changes in surface properties, including the closure of the deep hydrophobic cavity essential for target protein recognition. Concerted movements of helices A and D with respect to B and C, and of helices E and H with respect to F and G are likely responsible for the cooperative Ca(2+)-binding property observed between two adjacent EF-hand sites in the amino- and carboxy-terminal domains.

PubMed: 7552747
DOI: 10.1038/nsb0995-758

実験手法

SOLUTION NMR