1DLC

CRYSTAL STRUCTURE OF INSECTICIDAL DELTA-ENDOTOXIN FROM BACILLUS THURINGIENSIS AT 2.5 ANGSTROMS RESOLUTION

1DLC の概要

• エントリーDOI: 10.2210/pdb1dlc/pdb
• 分子名称: DELTA-ENDOTOXIN CRYIIIA (2 entities in total)
• 機能のキーワード: toxin
• 由来する生物種: Bacillus thuringiensis
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 66312.80

構造登録者

Li, J. (登録日: 1994-06-22, 公開日: 1994-09-30, 最終更新日: 2024-02-07)

主引用文献

Li, J.D.,Carroll, J.,Ellar, D.J.
Crystal structure of insecticidal delta-endotoxin from Bacillus thuringiensis at 2.5 A resolution.
Nature, 353:815-821, 1991

PubMed Abstract: The structure of the delta-endotoxin from Bacillus thuringiensis subsp. tenebrionis that is specifically toxic to Coleoptera insects (beetle toxin) has been determined at 2.5 A resolution. It comprises three domains which are, from the N- to C-termini, a seven-helix bundle, a three-sheet domain, and a beta sandwich. The core of the molecule encompassing all the domain interfaces is built from conserved sequence segments of the active delta-endotoxins. Therefore the structure represents the general fold of this family of insecticidal proteins. The bundle of long, hydrophobic and amphipathic helices is equipped for pore formation in the insect membrane, and regions of the three-sheet domain are probably responsible for receptor binding.

PubMed: 1658659
DOI: 10.1038/353815a0

実験手法

X-RAY DIFFRACTION (2.5 Å)