1DJO

Crystal structure of Pseudomonas 7A Glutaminase-asparaginase with the inhibitor donv covalently bound in the active site

1DJO の概要

• エントリーDOI: 10.2210/pdb1djo/pdb
• 関連するPDBエントリー: 1DJP 4PGA
• 分子名称: GLUTAMINASE-ASPARAGINASE, 4,4-dihydroxy-5-oxo-L-norvaline (2 entities in total)
• 機能のキーワード: pga, glutaminase, asparaginase, donv, 5-diazo-4-oxo-l-norvaline, glutaminase-asparaginase, suicide inhibitor, covalently bound inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Pseudomonas sp.
• 細胞内の位置: Periplasm: P10182
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 71118.30

構造登録者

Ortlund, E.,Lacount, M.W.,Lewinski, K.,Lebioda, L. (登録日: 1999-12-03, 公開日: 2000-01-24, 最終更新日: 2011-07-13)

• 主引用文献: Ortlund, E.,Lacount, M.W.,Lewinski, K.,Lebioda, L.; Reactions of Pseudomonas 7A glutaminase-asparaginase with diazo analogues of glutamine and asparagine result in unexpected covalent inhibitions and suggests an unusual catalytic triad Thr-Tyr-Glu.; Biochemistry, 39:1199-1204, 2000; PubMed: 10684596; DOI: 10.1021/bi991797d

実験手法

X-RAY DIFFRACTION (2 Å)