1DIF
HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285
Summary for 1DIF
Entry DOI | 10.2210/pdb1dif/pdb |
Descriptor | HIV-1 PROTEASE, BETA-MERCAPTOETHANOL, N-{1-BENZYL-2,2-DIFLUORO-3,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE, ... (4 entities in total) |
Functional Keywords | aspartic proteinase |
Biological source | Human immunodeficiency virus 1 |
Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 |
Total number of polymer chains | 2 |
Total formula weight | 22594.74 |
Authors | Silva, A.M.,Cachau, R.E.,Sham, H.L.,Erickson, J.W. (deposition date: 1995-10-09, release date: 1996-03-08, Last modification date: 2024-06-05) |
Primary citation | Silva, A.M.,Cachau, R.E.,Sham, H.L.,Erickson, J.W. Inhibition and catalytic mechanism of HIV-1 aspartic protease. J.Mol.Biol., 255:321-346, 1996 Cited by PubMed: 8551523DOI: 10.1006/jmbi.1996.0026 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.7 Å) |
Structure validation
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