1DIF

HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285

1DIF の概要

分子名称HIV-1 PROTEASE, BETA-MERCAPTOETHANOL, N-{1-BENZYL-2,2-DIFLUORO-3,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE, ... (4 entities in total)
機能のキーワードaspartic proteinase
由来する生物種Human immunodeficiency virus 1
細胞内の位置Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential) P03367
ポリマー鎖数2
分子量合計22594.74
構造登録者
Silva, A.M.,Cachau, R.E.,Sham, H.L.,Erickson, J.W. (登録日: 1995-10-09, 公開日: 1996-03-08, 最終更新日: 2011-07-13)
主引用文献
Silva, A.M.,Cachau, R.E.,Sham, H.L.,Erickson, J.W.
Inhibition and catalytic mechanism of HIV-1 aspartic protease.
J.Mol.Biol., 255:321-346, 1996
PubMed: 8551523 (主引用文献が同じPDBエントリー)
DOI: 10.1006/jmbi.1996.0026
MImport into Mendeley
実験手法
X-RAY DIFFRACTION (1.7 Å)
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構造検証レポート

ClashscoreRamachandran outliersSidechain outliers202.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
検証レポート(詳細版)をダウンロード

他の静止画像(非対称単位)

Molmil generated image of 1dif
回転なし
Molmil generated image of 1dif
x軸(左右方向)周りに90°回転
Molmil generated image of 1dif
y軸(上下方向)周りに90°回転