1DIF

HIV-1 PROTEASE IN COMPLEX WITH A DIFLUOROKETONE CONTAINING INHIBITOR A79285

1DIF の概要

• エントリーDOI: 10.2210/pdb1dif/pdb
• 分子名称: HIV-1 PROTEASE, BETA-MERCAPTOETHANOL, N-{1-BENZYL-2,2-DIFLUORO-3,3-DIHYDROXY-4-[3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRYLAMINO]-5-PHENYL-PENTYL}-3-METHYL-2-(3-METHYL-3-PYRIDIN-2-YLMETHYL-UREIDO)-BUTYRAMIDE, ... (4 entities in total)
• 機能のキーワード: aspartic proteinase
• 由来する生物種: Human immunodeficiency virus 1
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 22594.74

構造登録者

Silva, A.M.,Cachau, R.E.,Sham, H.L.,Erickson, J.W. (登録日: 1995-10-09, 公開日: 1996-03-08, 最終更新日: 2024-06-05)

• 主引用文献: Silva, A.M.,Cachau, R.E.,Sham, H.L.,Erickson, J.W.; Inhibition and catalytic mechanism of HIV-1 aspartic protease.; J.Mol.Biol., 255:321-346, 1996; PubMed: 8551523; DOI: 10.1006/jmbi.1996.0026

実験手法

X-RAY DIFFRACTION (1.7 Å)