1DHS

CRYSTAL STRUCTURE OF THE NAD COMPLEX OF HUMAN DEOXYHYPUSINE SYNTHASE

Summary for 1DHS

• Entry DOI: 10.2210/pdb1dhs/pdb
• Descriptor: DEOXYHYPUSINE SYNTHASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE (3 entities in total)
• Functional Keywords: spermidine, initiation factor 5a, nad, subunit interactions, oxidoreductase, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 40742.86

Authors

Liao, D.-I.,Davies, D.R. (deposition date: 1997-10-28, release date: 1998-02-25, Last modification date: 2024-02-07)

Primary citation

Liao, D.I.,Wolff, E.C.,Park, M.H.,Davies, D.R.
Crystal structure of the NAD complex of human deoxyhypusine synthase: an enzyme with a ball-and-chain mechanism for blocking the active site.
Structure, 6:23-32, 1998

PubMed Abstract: Eukaryotic initiation factor 5A (elF-5A) contains an unusual amino acid, hypusine [N epsilon-(4-aminobutyl-2-hydroxy)lysine]. The first step in the post-translational formation of hypusine is catalysed by the enzyme deoxyhypusine synthase (DHS). The modified version of elF-5A, and DHS, are required for eukaryotic cell proliferation. Knowledge of the three-dimensional structure of this key enzyme should permit the design of specific inhibitors that may be useful as anti-proliferative agents.

PubMed: 9493264
DOI: 10.1016/S0969-2126(98)00004-5

Experimental method

X-RAY DIFFRACTION (2.2 Å)