1DFJ

RIBONUCLEASE INHIBITOR COMPLEXED WITH RIBONUCLEASE A

1DFJ の概要

• エントリーDOI: 10.2210/pdb1dfj/pdb
• 分子名称: RIBONUCLEASE A, RIBONUCLEASE INHIBITOR, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: complex (ribonuclease-inhibitor), ribonuclease, hydrolase, leucine-rich repeats, complex (endonuclease-inhibitor) complex, complex (endonuclease/inhibitor)
• 由来する生物種: Bos taurus (cattle); 詳細
• 細胞内の位置: Secreted: P61823; Cytoplasm: P10775
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 62896.55

構造登録者

Kobe, B.,Deisenhofer, J. (登録日: 1996-06-29, 公開日: 1997-01-11, 最終更新日: 2024-10-16)

主引用文献

Kobe, B.,Deisenhofer, J.
A structural basis of the interactions between leucine-rich repeats and protein ligands.
Nature, 374:183-186, 1995

PubMed Abstract: The leucine-rich repeat is a recently characterized structural motif used in molecular recognition processes as diverse as signal transduction, cell adhesion, cell development, DNA repair and RNA processing. We present here the crystal structure at 2.5 A resolution of the complex between ribonuclease A and ribonuclease inhibitor, a protein built entirely of leucine-rich repeats. The unusual non-globular structure of ribonuclease inhibitor, its solvent-exposed parallel beta-sheet and the conformational flexibility of the structure are used in the interaction; they appear to be the principal reasons for the effectiveness of leucine-rich repeats as protein-binding motifs. The structure can serve as a model for the interactions of other proteins containing leucine-rich repeats with their ligands.

PubMed: 7877692
DOI: 10.1038/374183a0

実験手法

X-RAY DIFFRACTION (2.5 Å)