1DC0

CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG

Summary for 1DC0

• Entry DOI: 10.2210/pdb1dc0/pdb
• Descriptor: DNA (5'-D(*CP*AP*TP*GP*GP*GP*CP*CP*CP*AP*TP*G)-3') (2 entities in total)
• Functional Keywords: a-dna, b-dna, intermediate, dna
• Total number of polymer chains: 2
• Total formula weight: 7326.78

Authors

Ng, H.L.,Kopka, M.L.,Dickerson, R.E. (deposition date: 1999-11-03, release date: 2000-03-06, Last modification date: 2024-02-07)

Primary citation

Ng, H.L.,Kopka, M.L.,Dickerson, R.E.
The structure of a stable intermediate in the A ;-> B DNA helix transition
Proc.Natl.Acad.Sci.USA, 97:2035-2039, 2000

PubMed Abstract: The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.

PubMed: 10688897
DOI: 10.1073/pnas.040571197

Experimental method

X-RAY DIFFRACTION (1.3 Å)