1DC0

CRYSTAL STRUCTURE OF AN A/B-DNA INTERMEDIATE CATGGGCCCATG

1DC0 の概要

• エントリーDOI: 10.2210/pdb1dc0/pdb
• 分子名称: DNA (5'-D(*CP*AP*TP*GP*GP*GP*CP*CP*CP*AP*TP*G)-3') (2 entities in total)
• 機能のキーワード: a-dna, b-dna, intermediate, dna
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 7326.78

構造登録者

Ng, H.L.,Kopka, M.L.,Dickerson, R.E. (登録日: 1999-11-03, 公開日: 2000-03-06, 最終更新日: 2024-02-07)

主引用文献

Ng, H.L.,Kopka, M.L.,Dickerson, R.E.
The structure of a stable intermediate in the A ;-> B DNA helix transition
Proc.Natl.Acad.Sci.USA, 97:2035-2039, 2000

PubMed Abstract: The DNA dodecamer CATGGGCCCATG in a crystal structure of resolution 1.3 A has a conformation intermediate between A and B DNA. This trapping of a stable intermediate suggests that the A and B DNA families are not discrete, as previously believed. The structure supports a base-centered rather than a backbone-centered mechanism for the A <--> B transition mediated by guanine tracts. Interconversion between A and B DNA provides another means for regulating protein-DNA recognition.

PubMed: 10688897
DOI: 10.1073/pnas.040571197

実験手法

X-RAY DIFFRACTION (1.3 Å)