1DAN

Complex of active site inhibited human blood coagulation factor VIIA with human recombinant soluble tissue factor

1DAN の概要

• エントリーDOI: 10.2210/pdb1dan/pdb
• 関連するBIRD辞書のPRD_ID: PRD_000369
• 分子名称: BLOOD COAGULATION FACTOR VIIA light chain, CHLORIDE ION, BLOOD COAGULATION FACTOR VIIA heavy chain, ... (11 entities in total)
• 機能のキーワード: blood coagulation, serine protease, co-factor, receptor enzyme, gla, egf, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 70003.49

構造登録者

Banner, D.W. (登録日: 1997-03-05, 公開日: 1997-09-04, 最終更新日: 2020-07-29)

主引用文献

Banner, D.W.,D'Arcy, A.,Chene, C.,Winkler, F.K.,Guha, A.,Konigsberg, W.H.,Nemerson, Y.,Kirchhofer, D.
The crystal structure of the complex of blood coagulation factor VIIa with soluble tissue factor.
Nature, 380:41-46, 1996

PubMed Abstract: Blood coagulation is initiated when tissue factor binds to coagulation factor VIIa to give an enzymatically active complex which then activates factors IX and X, leading to thrombin generation and clot formation. We have determined the crystal structure at 2.0-A degrees resolution of active-site-inhibited factor VIIa complexed with the cleaved extracellular domain of tissue factor. In the complex, factor VIIa adopts an extended conformation. This structure provides a basis for understanding many molecular aspects of the initiation of coagulation.

PubMed: 8598903
DOI: 10.1038/380041a0

実験手法

X-RAY DIFFRACTION (2 Å)