1D4P

CRYSTAL STRUCTURE OF HUMAN ALPHA THROMBIN IN COMPLEX WITH 5-AMIDINOINDOLE-4-BENZYLPIPERIDINE INHIBITOR

1D4P の概要

• エントリーDOI: 10.2210/pdb1d4p/pdb
• 関連するPDBエントリー: 1D3D 1D3P 1D3Q 1D3T
• 分子名称: ALPHA-THROMBIN, HIRUGEN, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (7 entities in total)
• 機能のキーワード: thrombin; nonpeptidyl inhibitor; structure-based drug design, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 36052.97

構造登録者

Chirgadze, N.Y. (登録日: 1999-10-04, 公開日: 1999-10-20, 最終更新日: 2021-04-28)

• 主引用文献: Chirgadze, N.Y.,Sall, D.J.,Klimkowski, V.J.,Clawson, D.K.,Briggs, S.L.,Hermann, R.,Smith, G.F.,Gifford-Moore, D.S.,Wery, J.P.; The crystal structure of human alpha-thrombin complexed with LY178550, a nonpeptidyl, active site-directed inhibitor.; Protein Sci., 6:1412-1417, 1997; PubMed: 9232642

実験手法

X-RAY DIFFRACTION (2.07 Å)