1D3G

HUMAN DIHYDROOROTATE DEHYDROGENASE COMPLEXED WITH BREQUINAR ANALOG

1D3G の概要

• エントリーDOI: 10.2210/pdb1d3g/pdb
• 関連するPDBエントリー: 1D3H
• 分子名称: DIHYDROOROTATE DEHYDROGENASE, SULFATE ION, ACETATE ION, ... (8 entities in total)
• 機能のキーワード: protein-antiproliferative agent complex, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Mitochondrion inner membrane; Single-pass membrane protein: Q02127
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 41182.81

構造登録者

Liu, S.,Neidhardt, E.A.,Grossman, T.H.,Ocain, T.,Clardy, J. (登録日: 1999-09-29, 公開日: 2000-09-13, 最終更新日: 2024-02-07)

主引用文献

Liu, S.,Neidhardt, E.A.,Grossman, T.H.,Ocain, T.,Clardy, J.
Structures of human dihydroorotate dehydrogenase in complex with antiproliferative agents.
Structure Fold.Des., 8:25-33, 2000

PubMed Abstract: Dihydroorotate dehydrogenase (DHODH) catalyzes the fourth committed step in the de novo biosynthesis of pyrimidines. As rapidly proliferating human T cells have an exceptional requirement for de novo pyrimidine biosynthesis, small molecule DHODH inhibitors constitute an attractive therapeutic approach to autoimmune diseases, immunosuppression, and cancer. Neither the structure of human DHODH nor any member of its family was known.

PubMed: 10673429
DOI: 10.1016/S0969-2126(00)00077-0

実験手法

X-RAY DIFFRACTION (1.6 Å)