1CX8

CRYSTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR

Summary for 1CX8

• Entry DOI: 10.2210/pdb1cx8/pdb
• Descriptor: TRANSFERRIN RECEPTOR PROTEIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, SAMARIUM (III) ION (3 entities in total)
• Functional Keywords: human transferrin receptor, metal transport
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 8
• Total formula weight: 581901.32

Authors

Lawrence, C.M.,Ray, S.,Babyonyshev, M.,Galluser, R.,Borhani, D.,Harrison, S.C. (deposition date: 1999-08-28, release date: 1999-09-09, Last modification date: 2024-11-06)

Primary citation

Lawrence, C.M.,Ray, S.,Babyonyshev, M.,Galluser, R.,Borhani, D.W.,Harrison, S.C.
Crystal structure of the ectodomain of human transferrin receptor.
Science, 286:779-782, 1999

PubMed Abstract: The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling apotransferrin after discharge of iron in the endosome. The crystal structure of the dimeric ectodomain of the human TfR, determined here to 3.2 angstroms resolution, reveals a three-domain subunit. One domain closely resembles carboxy- and aminopeptidases, and features of membrane glutamate carboxypeptidase can be deduced from the TfR structure. A model is proposed for Tf binding to the receptor.

PubMed: 10531064
DOI: 10.1126/science.286.5440.779

Experimental method

X-RAY DIFFRACTION (3.2 Å)