1CX8

CRYSTAL STRUCTURE OF THE ECTODOMAIN OF HUMAN TRANSFERRIN RECEPTOR

1CX8 の概要

• エントリーDOI: 10.2210/pdb1cx8/pdb
• 分子名称: TRANSFERRIN RECEPTOR PROTEIN, 2-acetamido-2-deoxy-beta-D-glucopyranose, SAMARIUM (III) ION (3 entities in total)
• 機能のキーワード: human transferrin receptor, metal transport
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 8
• 化学式量合計: 581901.32

構造登録者

Lawrence, C.M.,Ray, S.,Babyonyshev, M.,Galluser, R.,Borhani, D.,Harrison, S.C. (登録日: 1999-08-28, 公開日: 1999-09-09, 最終更新日: 2024-11-06)

主引用文献

Lawrence, C.M.,Ray, S.,Babyonyshev, M.,Galluser, R.,Borhani, D.W.,Harrison, S.C.
Crystal structure of the ectodomain of human transferrin receptor.
Science, 286:779-782, 1999

PubMed Abstract: The transferrin receptor (TfR) undergoes multiple rounds of clathrin-mediated endocytosis and reemergence at the cell surface, importing iron-loaded transferrin (Tf) and recycling apotransferrin after discharge of iron in the endosome. The crystal structure of the dimeric ectodomain of the human TfR, determined here to 3.2 angstroms resolution, reveals a three-domain subunit. One domain closely resembles carboxy- and aminopeptidases, and features of membrane glutamate carboxypeptidase can be deduced from the TfR structure. A model is proposed for Tf binding to the receptor.

PubMed: 10531064
DOI: 10.1126/science.286.5440.779

実験手法

X-RAY DIFFRACTION (3.2 Å)