1CVW

Crystal structure of active site-inhibited human coagulation factor VIIA (DES-GLA)

Summary for 1CVW

Related1DAN
Related PRD IDPRD_000287
DescriptorCOAGULATION FACTOR VIIA (LIGHT CHAIN) (DES-GLA), COAGULATION FACTOR VIIA (HEAVY CHAIN) (DES-GLA), N-{[5-(dimethylamino)naphthalen-1-yl]sulfonyl}-L-alpha-glutamyl-N-[(2S,3S)-6-carbamimidamido-1-chloro-2-hydroxyhexan-3-yl]glycinamide, ... (5 entities in total)
Functional Keywordsblood coagulation, factor viia, serine protease, egf, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationSecreted P08709 P08709
Total number of polymer chains2
Total molecular weight34802.3
Authors
Kemball-Cook, G.,Johnson, D.J.D.,Tuddenham, E.G.D.,Harlos, K. (deposition date: 1999-08-24, release date: 1999-08-31, Last modification date: 2013-02-27)
Primary citation
Kemball-Cook, G.,Johnson, D.J.,Tuddenham, E.G.,Harlos, K.
Crystal structure of active site-inhibited human coagulation factor VIIa (des-Gla).
J.Struct.Biol., 127:213-223, 1999
PubMed: 10544046 (PDB entries with the same primary citation)
DOI: 10.1006/jsbi.1999.4158
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.28 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24180.3%2.3%7.1%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution