1CU1

CRYSTAL STRUCTURE OF AN ENZYME COMPLEX FROM HEPATITIS C VIRUS

1CU1 の概要

• エントリーDOI: 10.2210/pdb1cu1/pdb
• 分子名称: PROTEIN (PROTEASE/HELICASE NS3), ZINC ION, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: hepatitis c virus, bifunctional, protease-helicase, hydrolase
• 由来する生物種: Hepatitis C virus; 詳細
• 細胞内の位置: Core protein p21: Host endoplasmic reticulum membrane; Single-pass membrane protein. Core protein p19: Virion . Envelope glycoprotein E1: Virion membrane ; Single-pass type I membrane protein . Envelope glycoprotein E2: Virion membrane ; Single-pass type I membrane protein . p7: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Protease NS2-3: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 5A: Host endoplasmic reticulum membrane ; Peripheral membrane protein . RNA-directed RNA polymerase: Host endoplasmic reticulum membrane ; Single-pass type I membrane protein : P26663
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 137454.42

構造登録者

Yao, N.,Weber, P.C. (登録日: 1999-08-20, 公開日: 2000-08-23, 最終更新日: 2024-02-07)

• 主引用文献: Yao, N.,Reichert, P.,Taremi, S.S.,Prosise, W.W.,Weber, P.C.; Molecular views of viral polyprotein processing revealed by the crystal structure of the hepatitis C virus bifunctional protease-helicase.; Structure Fold.Des., 7:1353-1363, 1999; PubMed: 10574797; DOI: 10.1016/S0969-2126(00)80025-8

実験手法

X-RAY DIFFRACTION (2.5 Å)