1CQQ

TYPE 2 RHINOVIRUS 3C PROTEASE WITH AG7088 INHIBITOR

1CQQ の概要

• エントリーDOI: 10.2210/pdb1cqq/pdb
• 分子名称: TYPE 2 RHINOVIRUS 3C PROTEASE, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER (3 entities in total)
• 機能のキーワード: viral protein, hydrolase
• 由来する生物種: Human rhinovirus 2
• 細胞内の位置: Capsid protein VP0: Virion . Capsid protein VP4: Virion . Capsid protein VP2: Virion . Capsid protein VP3: Virion . Capsid protein VP1: Virion . Protein 2B: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 2C: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3A: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Protein 3AB: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . Viral protein genome-linked: Virion . Protease 3C: Host cytoplasm . Protein 3CD: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side . RNA-directed RNA polymerase: Host cytoplasmic vesicle membrane ; Peripheral membrane protein ; Cytoplasmic side : P04936
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 20582.34

構造登録者

Matthews, D.,Ferre, R.A. (登録日: 1999-08-10, 公開日: 1999-09-20, 最終更新日: 2018-01-31)

• 主引用文献: Matthews, D.A.,Dragovich, P.S.,Webber, S.E.,Fuhrman, S.A.,Patick, A.K.,Zalman, L.S.,Hendrickson, T.F.,Love, R.A.,Prins, T.J.,Marakovits, J.T.,Zhou, R.,Tikhe, J.,Ford, C.E.,Meador, J.W.,Ferre, R.A.,Brown, E.L.,Binford, S.L.,Brothers, M.A.,DeLisle, D.M.,Worland, S.T.; Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.; Proc.Natl.Acad.Sci.USA, 96:11000-11007, 1999; PubMed: 10500114; DOI: 10.1073/pnas.96.20.11000

実験手法

X-RAY DIFFRACTION (1.85 Å)