1COZ

CTP:GLYCEROL-3-PHOSPHATE CYTIDYLYLTRANSFERASE FROM BACILLUS SUBTILIS

1COZ の概要

• エントリーDOI: 10.2210/pdb1coz/pdb
• 分子名称: PROTEIN (GLYCEROL-3-PHOSPHATE CYTIDYLYLTRANSFERASE), CYTIDINE-5'-TRIPHOSPHATE (3 entities in total)
• 機能のキーワード: transferase
• 由来する生物種: Bacillus subtilis
• 細胞内の位置: Cytoplasm: P27623
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 31557.39

構造登録者

Weber, C.H.,Park, Y.S.,Sanker, S.,Kent, C.,Ludwig, M.L. (登録日: 1999-05-29, 公開日: 1999-10-06, 最終更新日: 2023-12-27)

主引用文献

Weber, C.H.,Park, Y.S.,Sanker, S.,Kent, C.,Ludwig, M.L.
A prototypical cytidylyltransferase: CTP:glycerol-3-phosphate cytidylyltransferase from bacillus subtilis.
Structure Fold.Des., 7:1113-1124, 1999

PubMed Abstract: The formation of critical intermediates in the biosynthesis of lipids and complex carbohydrates is carried out by cytidylyltransferases, which utilize CTP to form activated CDP-alcohols or CMP-acid sugars plus inorganic pyrophosphate. Several cytidylyltransferases are related and constitute a conserved family of enzymes. The eukaryotic members of the family are complex enzymes with multiple regulatory regions or repeated catalytic domains, whereas the bacterial enzyme, CTP:glycerol-3-phosphate cytidylyltransferase (GCT), contains only the catalytic domain. Thus, GCT provides an excellent model for the study of catalysis by the eukaryotic cytidylyltransferases.

PubMed: 10508782
DOI: 10.1016/S0969-2126(99)80178-6

実験手法

X-RAY DIFFRACTION (2 Å)