1COS

CRYSTAL STRUCTURE OF A SYNTHETIC TRIPLE-STRANDED ALPHA-HELICAL BUNDLE

1COS の概要

• エントリーDOI: 10.2210/pdb1cos/pdb
• 分子名称: COILED SERINE (2 entities in total)
• 機能のキーワード: alpha-helical bundle
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 10007.59

構造登録者

Lovejoy, B.,Choe, S.,Cascio, D.,Mcrorie, D.K.,Degrado, W.,Eisenberg, D. (登録日: 1993-01-22, 公開日: 1993-10-31, 最終更新日: 2024-11-06)

主引用文献

Lovejoy, B.,Choe, S.,Cascio, D.,McRorie, D.K.,DeGrado, W.F.,Eisenberg, D.
Crystal structure of a synthetic triple-stranded alpha-helical bundle.
Science, 259:1288-1293, 1993

PubMed Abstract: The x-ray crystal structure of a peptide designed to form a double-stranded parallel coiled coil shows that it is actually a triple-stranded coiled coil formed by three alpha-helices. Unlike the designed parallel coiled coil, the helices run up-up-down. The structure is stabilized by a distinctive hydrophobic interface consisting of eight layers. As in the design, each alpha-helix in the coiled coil contributes one leucine side chain to each layer. The structure suggests that hydrophobic interactions are a dominant factor in the stabilization of coiled coils. The stoichiometry and geometry of coiled coils are primarily determined by side chain packing in the solvent-inaccessible interior, but electrostatic interactions also contribute.

PubMed: 8446897

実験手法

X-RAY DIFFRACTION (2.1 Å)