1CHU

STRUCTURE OF L-ASPARTATE OXIDASE: IMPLICATIONS FOR THE SUCCINATE DEHYDROGENASE/ FUMARATE REDUCATSE FAMILY

1CHU の概要

• エントリーDOI: 10.2210/pdb1chu/pdb
• 分子名称: PROTEIN (L-ASPARTATE OXIDASE) (2 entities in total)
• 機能のキーワード: flavoenzyme, nad biosynthesis, fad, oxidoreductase
• 由来する生物種: Escherichia coli
• 細胞内の位置: Cytoplasm: P10902
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 60430.33

構造登録者

Mattevi, A. (登録日: 1999-03-29, 公開日: 1999-06-23, 最終更新日: 2023-12-27)

主引用文献

Mattevi, A.,Tedeschi, G.,Bacchella, L.,Coda, A.,Negri, A.,Ronchi, S.
Structure of L-aspartate oxidase: implications for the succinate dehydrogenase/fumarate reductase oxidoreductase family.
Structure Fold.Des., 7:745-756, 1999

PubMed Abstract: Given the vital role of NAD+ in cell metabolism, the enzymes involved in bacterial de novo NAD+ biosynthesis are possible targets for drug design against pathogenic bacteria. The first reaction in the pathway is catalysed by L-aspartate oxidase (LASPO), a flavoenzyme that converts aspartate to iminoaspartate using either molecular oxygen or fumarate as electron acceptors. LASPO has considerable sequence homology with the flavoprotein subunits of succinate dehydrogenase (SDH) and fumarate reductase (FRD).

PubMed: 10425677
DOI: 10.1016/S0969-2126(99)80099-9

実験手法

X-RAY DIFFRACTION (2.2 Å)