1CFJ

METHYLPHOSPHONYLATED ACETYLCHOLINESTERASE (AGED) OBTAINED BY REACTION WITH O-ISOPROPYLMETHYLPHOSPHONOFLUORIDATE (GB, SARIN)

1CFJ の概要

• エントリーDOI: 10.2210/pdb1cfj/pdb
• 分子名称: PROTEIN (ACETYLCHOLINESTERASE), 2-acetamido-2-deoxy-beta-D-glucopyranose, METHYLPHOSPHONIC ACID ESTER GROUP, ... (4 entities in total)
• 機能のキーワード: cholinesterase, organophosphate, serine hydrolase, chemical-warfare, hydrolase
• 由来する生物種: Torpedo californica (Pacific electric ray)
• 細胞内の位置: Isoform H: Cell membrane; Lipid-anchor, GPI- anchor. Isoform T: Cell membrane; Peripheral membrane protein: P04058
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 61274.95

構造登録者

Millard, C.B.,Silman, I.,Sussman, J.L. (登録日: 1999-03-19, 公開日: 1999-06-25, 最終更新日: 2023-08-09)

• 主引用文献: Millard, C.B.,Kryger, G.,Ordentlich, A.,Greenblatt, H.M.,Harel, M.,Raves, M.L.,Segall, Y.,Barak, D.,Shafferman, A.,Silman, I.,Sussman, J.L.; Crystal structures of aged phosphonylated acetylcholinesterase: nerve agent reaction products at the atomic level.; Biochemistry, 38:7032-7039, 1999; PubMed: 10353814; DOI: 10.1021/bi982678l

実験手法

X-RAY DIFFRACTION (2.6 Å)