1CDW

HUMAN TBP CORE DOMAIN COMPLEXED WITH DNA

1CDW の概要

• エントリーDOI: 10.2210/pdb1cdw/pdb
• 分子名称: DNA (5'-D(*CP*TP*GP*CP*TP*AP*TP*AP*AP*AP*AP*GP*GP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*CP*CP*TP*TP*TP*TP*AP*TP*AP*GP*CP*AP*G)-3'), PROTEIN (TATA BINDING PROTEIN (TBP)), ... (4 entities in total)
• 機能のキーワード: transcription initiation, dna binding, complex (transcription factor-dna), transcription-dna complex, transcription/dna
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 30022.41

構造登録者

Nikolov, D.B.,Chen, H.,Halay, E.D.,Hoffmann, A.,Roeder, R.G.,Burley, S.K. (登録日: 1996-04-11, 公開日: 1996-12-23, 最終更新日: 2024-04-03)

主引用文献

Nikolov, D.B.,Chen, H.,Halay, E.D.,Hoffman, A.,Roeder, R.G.,Burley, S.K.
Crystal structure of a human TATA box-binding protein/TATA element complex.
Proc.Natl.Acad.Sci.USA, 93:4862-4867, 1996

PubMed Abstract: The TATA box-binding protein (TBP) is required by all three eukaryotic RNA polymerases for correct initiation of transcription of ribosomal, messenger, small nuclear, and transfer RNAs. The cocrystal structure of the C-terminal/core region of human TBP complexed with the TATA element of the adenovirus major late promoter has been determined at 1.9 angstroms resolution. Structural and functional analyses of the protein-DNA complex are presented, with a detailed comparison to our 1.9-angstroms resolution structure of Arabidopsis thaliana TBP2 bound to the same TATA box.

PubMed: 8643494
DOI: 10.1073/pnas.93.10.4862

実験手法

X-RAY DIFFRACTION (1.9 Å)