1CDR

STRUCTURE OF A SOLUBLE, GLYCOSYLATED FORM OF THE HUMAN COMPLEMENT REGULATORY PROTEIN CD59

1CDR の概要

• エントリーDOI: 10.2210/pdb1cdr/pdb
• 分子名称: CD59, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose (2 entities in total)
• 機能のキーワード: complement regulatory protein
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 9540.65

構造登録者

Fletcher, C.M.,Harrison, R.A.,Lachmann, P.J.,Neuhaus, D. (登録日: 1994-06-01, 公開日: 1994-09-30, 最終更新日: 2024-11-06)

主引用文献

Fletcher, C.M.,Harrison, R.A.,Lachmann, P.J.,Neuhaus, D.
Structure of a soluble, glycosylated form of the human complement regulatory protein CD59.
Structure, 2:185-199, 1994

PubMed Abstract: CD59 is a cell-surface glycoprotein that protects host cells from complement-mediated lysis by binding to and preventing the normal functioning of the complement proteins C8 and/or C9 which form part of a membrane penetrating assembly called the membrane attack complex. CD59 has no structural similarity to other complement proteins, but is an example of a plasma protein domain type found also in murine Ly-6 proteins and the urokinase-type plasminogen activator receptor.

PubMed: 7520819
DOI: 10.1016/S0969-2126(00)00020-4

実験手法

SOLUTION NMR