1CDE

STRUCTURES OF APO AND COMPLEXED ESCHERICHIA COLI GLYCINAMIDE RIBONUCLEOTIDE TRANSFORMYLASE

1CDE の概要

• エントリーDOI: 10.2210/pdb1cde/pdb
• 関連するPDBエントリー: 1CDD
• 分子名称: PHOSPHORIBOSYL-GLYCINAMIDE FORMYLTRANSFERASE, GLYCINAMIDE RIBONUCLEOTIDE, 5-DEAZAFOLIC ACID (3 entities in total)
• 機能のキーワード: transferase(formyl)
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 95963.29

構造登録者

Almassy, R.J.,Janson, C.A.,Kan, C.-C.,Hostomska, Z. (登録日: 1992-05-15, 公開日: 1993-10-31, 最終更新日: 2024-02-07)

主引用文献

Almassy, R.J.,Janson, C.A.,Kan, C.C.,Hostomska, Z.
Structures of apo and complexed Escherichia coli glycinamide ribonucleotide transformylase.
Proc.Natl.Acad.Sci.USA, 89:6114-6118, 1992

PubMed Abstract: The three-dimensional structure of phosphoribosylglycinamide formyltransferase (10-formyltetrahydrofolate:5'-phosphoribosylglycinamide formyltransferase, EC 2.1.2.2) has been solved both as an apoenzyme at 2.8-A resolution and as a ternary complex with the substrate glycinamide ribonucleotide and a folate inhibitor at 2.5-A resolution. The structure is a modified doubly wound alpha/beta sheet with flexibility in the active site, including a disordered loop in the apo structure, which is ordered in the ternary complex structure. This enzyme is a target for anti-cancer therapy and now for structure-based drug design.

PubMed: 1631098
DOI: 10.1073/pnas.89.13.6114

実験手法

X-RAY DIFFRACTION (2.5 Å)